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Disorders of Gut–Brain Interaction

A group of disorders classified by gastrointestinal symptoms related to any combination of the following: motility disturbance, visceral hypersensitivity, altered mucosal and immune function, altered gut microbiota, and altered central nervous system processing.

Disorders of the gut brain axis are associated with recurrent abdominal pain, bloating and an altered bowel habit.

The best management for disorders of the gut brain axis requires an integrated approach. This approach takes into consideration:

• Early life influences: genetics, culture, environment.
• Psychosocial factors: stress, personality, social support.
• Physiology: motility, immune function, microflora and diet

Drossman D.Functional gastrointestinal disorders history pathophysiology clinical features and rome IV Gastroenterology 2016;150:1262–1279. Accessed: https://theromefoundation.org/wp-content/uploads/functional-gastrointestinal-disorders-history-pathophysiology-clinical-features-and-rome-iv.pdf (03-07-2020)